OR52K2

Protein-coding gene in the species Homo sapiens
OR52K2
Identifiers
AliasesOR52K2, OR11-7, olfactory receptor family 52 subfamily K member 2
External IDsMGI: 3030386; HomoloGene: 73941; GeneCards: OR52K2; OMA:OR52K2 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR52K2
Genomic location for OR52K2
Band11p15.4Start4,449,295 bp[1]
End4,450,361 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for OR52K2
Genomic location for OR52K2
Band7|7 E3Start102,246,977 bp[2]
End102,257,332 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • monocyte

  • blood

  • appendix

  • connective tissue

  • adipose tissue

  • subcutaneous adipose tissue
Top expressed in
  • respiratory epithelium

  • granulocyte

  • peripheral nervous system

  • nasal epithelium

  • olfactory epithelium

  • hippocampus proper

  • thymus

  • Cortex of frontal lobe

  • striatum of neuraxis

  • superior frontal gyrus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

119774

259106

Ensembl

ENSG00000181963

ENSMUSG00000073973

UniProt

Q8NGK3

E9Q545

RefSeq (mRNA)

NM_001005172

NM_147102

RefSeq (protein)

NP_001005172

NP_667313

Location (UCSC)Chr 11: 4.45 – 4.45 MbChr 7: 102.25 – 102.26 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 52K2 is a protein that in humans is encoded by the OR52K2 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181963 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000073973 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR52K2 olfactory receptor, family 52, subfamily K, member 2".

Further reading

  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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