OR1I1

Protein-coding gene in the species Homo sapiens
OR1I1
Identifiers
AliasesOR1I1, OR19-20, OR1I1P, OR1I1Q, olfactory receptor family 1 subfamily I member 1
External IDsMGI: 3031191; HomoloGene: 72920; GeneCards: OR1I1; OMA:OR1I1 - orthologs
Gene location (Human)
Chromosome 19 (human)
Chr.Chromosome 19 (human)[1]
Chromosome 19 (human)
Genomic location for OR1I1
Genomic location for OR1I1
Band19p13.12Start15,082,211 bp[1]
End15,092,970 bp[1]
Gene location (Mouse)
Chromosome 10 (mouse)
Chr.Chromosome 10 (mouse)[2]
Chromosome 10 (mouse)
Genomic location for OR1I1
Genomic location for OR1I1
Band10|10 C1Start78,446,837 bp[2]
End78,453,908 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • tibialis anterior muscle

  • gonad

  • mucosa of ileum

  • testicle

  • deltoid muscle

  • skin of hip

  • skin of thigh

  • placenta

  • blood

  • gastric mucosa
Top expressed in
  • respiratory epithelium

  • nasal epithelium

  • olfactory epithelium

  • olfactory bulb
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • signal transducer activity
  • transmembrane signaling receptor activity
  • olfactory receptor activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • response to stimulus
  • signal transduction
  • sensory perception of smell
  • detection of chemical stimulus involved in sensory perception of smell
  • detection of chemical stimulus involved in sensory perception
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

126370

257883

Ensembl

ENSG00000094661

ENSMUSG00000071185

UniProt

O60431

Q7TQU7

RefSeq (mRNA)

NM_001004713

NM_001011737

RefSeq (protein)

NP_001004713

NP_001011737

Location (UCSC)Chr 19: 15.08 – 15.09 MbChr 10: 78.45 – 78.45 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 1I1 is a protein that in humans is encoded by the OR1I1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000094661 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000071185 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR1I1 olfactory receptor, family 1, subfamily I, member 1".

Further reading

  • Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. CiteSeerX 10.1.1.135.3652. doi:10.1006/geno.2002.6830. PMID 12213199.
  • Grimwood J, Gordon LA, Olsen A, et al. (2004). "The DNA sequence and biology of human chromosome 19". Nature. 428 (6982): 529–35. Bibcode:2004Natur.428..529G. doi:10.1038/nature02399. PMID 15057824.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13