OR51I1

Protein-coding gene in the species Homo sapiens
OR51I1
Identifiers
AliasesOR51I1, olfactory receptor family 51 subfamily I member 1
External IDsMGI: 3030474; HomoloGene: 17404; GeneCards: OR51I1; OMA:OR51I1 - orthologs
Gene location (Human)
Chromosome 11 (human)
Chr.Chromosome 11 (human)[1]
Chromosome 11 (human)
Genomic location for OR51I1
Genomic location for OR51I1
Band11p15.4Start5,440,570 bp[1]
End5,441,514 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for OR51I1
Genomic location for OR51I1
Band7|7 E3Start103,667,893 bp[2]
End103,674,780 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • right uterine tube

  • respiratory system

  • subdivision of respiratory system

  • lower respiratory tract

  • lung

  • left uterine tube
Top expressed in
  • respiratory epithelium

  • nasal epithelium

  • olfactory epithelium
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • G protein-coupled receptor activity
  • olfactory receptor activity
  • signal transducer activity
Cellular component
  • integral component of membrane
  • plasma membrane
  • membrane
Biological process
  • sensory perception of smell
  • signal transduction
  • response to stimulus
  • detection of chemical stimulus involved in sensory perception of smell
  • G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

390063

258819

Ensembl

ENSG00000167359

ENSMUSG00000066262

UniProt

Q9H343

E9Q7P5

RefSeq (mRNA)

NM_001005288

NM_146822

RefSeq (protein)

NP_001005288

NP_667033

Location (UCSC)Chr 11: 5.44 – 5.44 MbChr 7: 103.67 – 103.67 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Olfactory receptor 51I1 is a protein that in humans is encoded by the OR51I1 gene.[5]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167359 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000066262 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: OR51I1 olfactory receptor, family 51, subfamily I, member 1".

Further reading

  • Bulger M, van Doorninck JH, Saitoh N, et al. (1999). "Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes". Proc. Natl. Acad. Sci. U.S.A. 96 (9): 5129–34. Bibcode:1999PNAS...96.5129B. doi:10.1073/pnas.96.9.5129. PMC 21828. PMID 10220430.
  • Bulger M, Bender MA, van Doorninck JH, et al. (2001). "Comparative structural and functional analysis of the olfactory receptor genes flanking the human and mouse beta-globin gene clusters". Proc. Natl. Acad. Sci. U.S.A. 97 (26): 14560–5. Bibcode:2000PNAS...9714560B. doi:10.1073/pnas.97.26.14560. PMC 18958. PMID 11121057.
  • Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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Class I
(fish-like receptors)
Family 51
Family 52
Family 56
Class II
(tetrapod specific receptors)
Family 1
Family 2
Family 3
Family 4
Family 5
Family 6
Family 7
Family 8
Family 9
Family 10
Family 11
Family 12
Family 13


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