PAX6

PAX6
Uygun yapılar
PDBOrtolog araması: PDBe RCSB
PDB kimlik kodlarının listesi

2CUE, 6PAX

Tanımlayıcılar
Başka adlarPAX6
Dış kimliklerOMIM: 607108 MGI: 97490 HomoloGene: 1212 GeneCards: PAX6
Gen yerleşimi (İnsan)
11. Kromozom (insan)
Krom.11. Kromozom (insan)[1]
11. Kromozom (insan)
PAX6 için genom yerleşimi
PAX6 için genom yerleşimi
Bant11p13Başlangıç31,784,779 [1]
Bitiş31,818,062 [1]
RNA ekspresyonu deseni
Daha çok ekspresyon verisi başvurusu
Gen ontolojisi
Moleküler işlevi GO:0001948, GO:0016582 protein bağlanması
DNA binding
sequence-specific DNA binding
GO:0050372 ubiquitin-protein transferase activity
GO:0001077, GO:0001212, GO:0001213, GO:0001211, GO:0001205 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific
chromatin binding
GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity
transcription factor binding
protein kinase binding
ubiquitin protein ligase binding
histone acetyltransferase binding
co-SMAD binding
R-SMAD binding
HMG box domain binding
GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding
RNA polymerase II core promoter sequence-specific DNA binding
GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific
Hücresel bileşeni sitoplazma
hücre çekirdeği
Nükleoplazma
Sitozol
intracellular anatomical structure
Biyolojik süreci eye development
blood vessel development
animal organ morphogenesis
GO:0009373 regulation of transcription, DNA-templated
glucose homeostasis
transcription, DNA-templated
central nervous system development
response to wounding
cell differentiation
cornea development in camera-type eye
negative regulation of neurogenesis
görsel algı
iris morphogenesis
multicellular organism development
neuron fate commitment
protein ubiquitination
GO:1901227 negative regulation of transcription by RNA polymerase II
establishment of mitotic spindle orientation
cell fate determination
neuron migration
GO:0033128 negative regulation of protein phosphorylation
positive regulation of neuroblast proliferation
lens development in camera-type eye
regionalization
type B pancreatic cell differentiation
pancreatic A cell development
GO:0044324, GO:0003256, GO:1901213, GO:0046019, GO:0046020, GO:1900094, GO:0061216, GO:0060994, GO:1902064, GO:0003258, GO:0072212 regulation of transcription by RNA polymerase II
transcription by RNA polymerase II
smoothened signaling pathway
axonogenesis
axon guidance
brain development
salivary gland morphogenesis
negative regulation of cell population proliferation
regulation of asymmetric cell division
dorsal/ventral axis specification
anterior/posterior pattern specification
dorsal/ventral pattern formation
Gen ifadesinin düzenlenmesi
GO:1901313 positive regulation of gene expression
pallium development
oligodendrocyte cell fate specification
cerebral cortex regionalization
forebrain dorsal/ventral pattern formation
commitment of neuronal cell to specific neuron type in forebrain
forebrain-midbrain boundary formation
telencephalon regionalization
pituitary gland development
habenula development
signal transduction involved in regulation of gene expression
keratinocyte differentiation
regulation of cell migration
positive regulation of epithelial cell differentiation
forebrain development
lacrimal gland development
protein localization to organelle
eye photoreceptor cell development
camera-type eye development
cell fate commitment
negative regulation of neuron differentiation
GO:0060469, GO:0009371 positive regulation of transcription, DNA-templated
GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II
regulation of timing of cell differentiation
embryonic camera-type eye morphogenesis
astrocyte differentiation
negative regulation of epithelial cell proliferation
regulation of neurogenesis
retina development in camera-type eye
cellular response to leukemia inhibitory factor
negative regulation of neural precursor cell proliferation
positive regulation of core promoter binding
Kaynaklar:Amigo / QuickGO
Ortologlar
TürlerİnsanFare
Entrez

5080

18508

Ensembl

ENSG00000007372

ENSMUSG00000027168

UniProt

P26367

P63015

RefSeq (mRNA)
NM_000280
NM_001127612
NM_001258462
NM_001258463
NM_001258464

NM_001258465
NM_001310158
NM_001310159
NM_001310160
NM_001310161
NM_001604

NM_001244198
NM_001244200
NM_001244201
NM_001244202
NM_013627

NM_001310144
NM_001310145
NM_001310146

RefSeq (protein)
NP_000271
NP_001121084
NP_001245391
NP_001245392
NP_001245393

NP_001245394
NP_001297087
NP_001297088
NP_001297089
NP_001297090
NP_001595
NP_001355816
NP_001355817
NP_001355818
NP_001355819
NP_001355820
NP_001355821
NP_001355822
NP_001355823
NP_001355828
NP_001355829
NP_001355830
NP_001355831
NP_001355832
NP_001355833
NP_001355834
NP_001355835
NP_001355836
NP_001355837
NP_001355838
NP_001355839
NP_001355840
NP_001355841
NP_001355842
NP_001355843
NP_001355844
NP_001355845
NP_001355846
NP_001355847
NP_001355848
NP_001355849
NP_001355850
NP_001355851
NP_001355852
NP_001355853
NP_001355854
NP_001355855
NP_001355856
NP_001355857
NP_001355858
NP_001355859

NP_001231127
NP_001231129
NP_001231130
NP_001231131
NP_001297073

NP_001297074
NP_001297075
NP_038655

Yerleşim (UCSC)Krom. 11: 31.78 – 31.82 Mbn/a
PubMed araması[2][3]
Vikiveri
İnsan'ı Gör/DüzenleFare'yi Gör/Düzenle

Aniridia tip II proteini (AN2) veya oculorhombin olarak da bilinen, insanların 11. kromozomunda yer alan PAX6 geni tarafından kodlanan bir proteindir.[4]

Kaynakça

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000007372 - Ensembl, May 2017
  2. ^ "İnsan PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arşivlenmesi gereken bağlantıya sahip kaynak şablonu içeren maddeler (link)
  3. ^ "Fare PubMed Başvurusu:". National Center for Biotechnology Information, U.S. National Library of Medicine. Arşivlenmesi gereken bağlantıya sahip kaynak şablonu içeren maddeler (link)
  4. ^ Jordan T, Hanson I, Zaletayev D, Hodgson S, Prosser J, Seawright A, Hastie N, van Heyningen V (August 1992). "The human PAX6 gene is mutated in two patients with aniridia". Nature Genetics. 1 (5). ss. 328-32. doi:10.1038/ng0892-328. PMID 1302030.