Formil peptidni receptor 3

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Formil peptidni receptor 3
Identifikatori
SimboliFPR3; FPRL2; FMLPY; RMLP-R-I
Vanjski IDOMIM: 136539 MGI: 1194495 HomoloGene: 40605 IUPHAR: FPR3 GeneCards: FPR3 Gene
Ontologija gena
Molekularna funkcija • aktivnost rodopsinu sličnog receptora
• receptorska aktivnost
• aktivnost N-formil peptidnog receptora
Celularna komponenta • ćelijska membrana
• integralno sa membranom
Biološki proces • ćelijska motilnost
• hemotaksa
• prenos signala
• signalni put G-protein spregnutog receptora
Pregled RNK izražavanja
podaci
Ortolozi
VrstaČovekMiš
Entrez235914294
EnsemblENSG00000187474ENSMUSG00000079700
UniProtP25089O08790
RefSeq (mRNA)NM_002030NM_008042
RefSeq (protein)NP_002021NP_032068
Lokacija (UCSC)Chr 19:
56.99 - 57.02 Mb		Chr 17:
18.02 - 18.11 Mb
PubMed pretraga[1][2]

N-formil peptidni receptor 3 je protein koji je kod ljudi kodiran FPR3 genom.[1][2][3]

Vidi još

  • Formil peptidni receptor

Literatura

  1. ↑ Bao L, Gerard NP, Eddy RL Jr, Shows TB, Gerard C (Jul 1992). „Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19”. Genomics 13 (2): 437–40. DOI:10.1016/0888-7543(92)90265-T. PMID 1612600. 
  2. ↑ Durstin M, Gao JL, Tiffany HL, McDermott D, Murphy PM (Jun 1994). „Differential expression of members of the N-formylpeptide receptor gene cluster in human phagocytes”. Biochem Biophys Res Commun 201 (1): 174–9. DOI:10.1006/bbrc.1994.1685. PMID 8198572. 
  3. ↑ „Entrez Gene: FPRL2 formyl peptide receptor-like 2”. 

Dodatna literatura

  • Christophe T, Karlsson A, Dugave C, et al. (2001). „The synthetic peptide Trp-Lys-Tyr-Met-Val-Met-NH2 specifically activates neutrophils through FPRL1/lipoxin A4 receptors and is an agonist for the orphan monocyte-expressed chemoattractant receptor FPRL2.”. J. Biol. Chem. 276 (24): 21585–93. DOI:10.1074/jbc.M007769200. PMID 11285256. 
  • Yang D, Chen Q, Gertz B, et al. (2002). „Human dendritic cells express functional formyl peptide receptor-like-2 (FPRL2) throughout maturation.”. J. Leukoc. Biol. 72 (3): 598–607. PMID 12223529. 
  • Christophe T, Karlsson A, Rabiet MJ, et al. (2002). „Phagocyte activation by Trp-Lys-Tyr-Met-Val-Met, acting through FPRL1/LXA4R, is not affected by lipoxin A4.”. Scand. J. Immunol. 56 (5): 470–6. DOI:10.1046/j.1365-3083.2002.01149.x. PMID 12410796. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). „Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. DOI:10.1073/pnas.242603899. PMC 139241. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). „Complete sequencing and characterization of 21,243 full-length human cDNAs.”. Nat. Genet. 36 (1): 40–5. DOI:10.1038/ng1285. PMID 14702039. 
  • Ernst S, Lange C, Wilbers A, et al. (2004). „An annexin 1 N-terminal peptide activates leukocytes by triggering different members of the formyl peptide receptor family.”. J. Immunol. 172 (12): 7669–76. PMID 15187149. 
  • Harada M, Habata Y, Hosoya M, et al. (2004). „N-Formylated humanin activates both formyl peptide receptor-like 1 and 2.”. Biochem. Biophys. Res. Commun. 324 (1): 255–61. DOI:10.1016/j.bbrc.2004.09.046. PMID 15465011. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). „The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).”. Genome Res. 14 (10B): 2121–7. DOI:10.1101/gr.2596504. PMC 528928. PMID 15489334. 
  • Kang HK, Lee HY, Kim MK, et al. (2005). „The synthetic peptide Trp-Lys-Tyr-Met-Val-D-Met inhibits human monocyte-derived dendritic cell maturation via formyl peptide receptor and formyl peptide receptor-like 2.”. J. Immunol. 175 (2): 685–92. PMID 16002663. 
  • Lee HY, Lee SY, Shin EH, et al. (2007). „F2L, a peptide derived from heme-binding protein, inhibits formyl peptide receptor-mediated signaling.”. Biochem. Biophys. Res. Commun. 359 (4): 985–90. DOI:10.1016/j.bbrc.2007.06.001. PMID 17577578. 

Spoljašnje veze

  • „Formylpeptide Receptors: FPRL2”. IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Arhivirano iz originala na datum 2015-05-18. 
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Klasa A: Rodopsinu slični
α1 (A, B, D) • α2 (A, B, C) • β1 • β2 • β3
Adenozinski (A1, A2A, A2B, A3) • P2Y (1, 2, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14)
(svi osim 5-HT3) 5-HT1 (A, B, D, E, F) • 5-HT2 (A, B, C) • 5-HT (4, 5A, 6, 7)
Drugi
Acetilholin (M1, M2, M3, M4, M5) • Dopamin (D1, D2, D3, D4, D5) • Histamin (H1, H2, H3, H4) • Melatonin (1A, 1B, 1C) • TAAR (1, 2, 3, 5, 6, 8, 9)
Metaboliti i
signalni molekuli
CysLT (1, 2) • LTB4 (1, 2) • FPRL1 • OXE • Prostaglandin (DP (1, 2), EP (1, 2, 3, 4), FP) • Prostaciklin • Tromboksan
Drugi
Žučna kiselina • Kanabinoidni (CB1, CB2, GPR (18, 55, 119)) • EBI2 • Estrogen • Slobodna masna kiselina (1, 2, 3, 4) • Laktat  • Lizofosfatidna kiselina (1, 2, 3, 4, 5, 6)  • Lizofosfolipid (1, 2, 3, 4, 5, 6, 7, 8) • Niacin (1, 2) • Oksoglutarat • PAF • Sfingozin-1-fosfat (1, 2, 3, 4, 5) • Sukcinat
Peptid
B/W (1, 2) • FF (1, 2) • S • Y (1, 2, 4, 5) • Neuromedin (B, U (1, 2)) • Neurotenzin (1, 2)
Drugi
Anafilatoksin (C3a, C5a) • Angiotenzin (1, 2) • Apelin • Bombezin (BRS3, GRPR, NMBR) • Bradikinin (B1, B2) • Hemokin • Holecistokinin (A, B) • Endotelin (A, B) • Formil peptid (1, 2, 3) • FSH • Galanin (1, 2, 3) • GHB receptor • Gonadotropin-oslobađajući hormon (1, 2) • Grelin • Kispeptin • Luteinizirajući hormon/horiogonadotropin • MAS (1, 1L, D, E, F, G, X1, X2, X3, X4) • Melanokortin (1, 2, 3, 4, 5) • MCHR (1, 2) • Motilin • Opioidni (δ, κ, μ, Nociceptin & ζ, ali ne σ) • Oreksin (1, 2) • Oksitocin • Prokineticin (1, 2) • Prolaktin-oslobađajući peptid • Relaksin (1, 2, 3, 4) • Somatostatin (1, 2, 3, 4, 5) • Tahikinin (1, 2, 3) • Tirotropin • Tirotropin-oslobađajući hormon • Urotenzin-II • Vazopresin (1A, 1B, 2)
Razno
GPR (1, 3, 4, 6, 12, 15, 17, 18, 19, 20, 21, 22, 23, 25, 26, 27, 31, 32, 33, 34, 35, 37, 39, 42, 44, 45, 50, 52, 55, 61, 62, 63, 65, 68, 75, 77, 78, 81, 82, 83, 84, 85, 87, 88, 92, 101, 103, 109A, 109B, 119, 120, 132, 135, 137B, 139, 141, 142, 146, 148, 149, 150, 151, 152, 153, 160, 161, 162, 171, 173, 174, 176, 177, 182, 183)
Drugi
Adrenomedulin • Mirisni • Opsin (3, 4, 5, 1LW, 1MW, 1SW, RGR, RRH) • Proteazom-aktivirani (1, 2, 3, 4) • SREB (1, 2, 3)
Klasa B: Sekretinu slični
GPR (56, 64, 97, 98, 110, 111, 112, 113, 114, 115, 116, 123, 124, 125, 126, 128, 133, 143, 144, 155, 157)
Drugi
Klasa C: Metabotropni
glutamat / feromon
TAS1R (1, 2, 3) • TAS2R (1, 3, 4, 5, 8, 9, 10, 12, 13, 14, 16, 19, 20, 30, 31, 38, 39, 40, 41, 42, 43, 45, 46, 50)
Drugi
Klasa F:
Frizzled / Zaglađeni
Uvojiti
Frizzled (1, 2, 3, 4, 5, 6, 7, 8, 9, 10)
Zaglađeni
B trdu: peptidi (nrpl/grfl/cytl/horl), receptori (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd, signalni putevi (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)