WNT7B

Wnt7b is a signaling protein that plays a crucial role for many developmental processes including placental, lung, eye, dendrite, and bone formation along with kidney development. The primary role of Wnt7b is to establish the cortico-medullary axis of epithelial organization.

WNT7B
Identifiers
Aliases	WNT7B, Wnt family member 7B
External IDs	OMIM: 601967; MGI: 98962; HomoloGene: 22531; GeneCards: WNT7B; OMA:WNT7B - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q13.31 Start 45,920,366 bp[1] End 45,977,162 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E2|15 40.39 cM Start 85,419,638 bp[2] End 85,466,674 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in vena cava buccal mucosa cell olfactory zone of nasal mucosa mucosa of pharynx skin of abdomen nipple skin of leg renal medulla mucosa of esophagus amygdala Top expressed in epithelium of male urethra epithelium of lens esophagus lumbar subsegment of spinal cord set of lens fibers medullary collecting duct subiculum ganglionic eminence transitional epithelium of urinary bladder dentate gyrus of hippocampal formation granule cell More reference expression data BioGPS n/a
Gene ontology Molecular function frizzled binding signaling receptor binding receptor ligand activity Cellular component endocytic vesicle membrane endoplasmic reticulum lumen extracellular region Golgi lumen extracellular exosome plasma membrane cytoplasm extracellular space Biological process cellular response to retinoic acid cell fate commitment renal inner medulla development lung morphogenesis mammary gland epithelium development stem cell proliferation embryonic organ development lung development renal outer medulla development embryonic placenta morphogenesis synapse organization metanephric epithelium development in utero embryonic development trachea cartilage morphogenesis chorio-allantoic fusion multicellular organism development developmental growth involved in morphogenesis forebrain regionalization positive regulation of osteoblast differentiation cell metabolism metanephric loop of Henle development neuron differentiation central nervous system vasculogenesis fibroblast proliferation lobar bronchus development metanephros morphogenesis inner medullary collecting duct development metanephric collecting duct development establishment or maintenance of polarity of embryonic epithelium lung epithelium development outer medullary collecting duct development oxygen homeostasis lens fiber cell development homeostatic process regulation of cell projection size response to glucocorticoid neuron projection morphogenesis Wnt signaling pathway neuron projection development positive regulation of JNK cascade canonical Wnt signaling pathway regulation of signaling receptor activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7477 22422 Ensembl ENSG00000188064 ENSMUSG00000022382 UniProt P56706 P28047 RefSeq (mRNA) NM_058238 NM_001163633 NM_001163634 NM_009528 RefSeq (protein) NP_478679 NP_001157105 NP_001157106 NP_033554 Location (UCSC) Chr 22: 45.92 – 45.98 Mb Chr 15: 85.42 – 85.47 Mb PubMed search [3] [4]
Wikidata
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Protein Wnt-7b is a protein that in humans is encoded by the WNT7B gene.^[5][6][7][8]

Function

The WNT gene family consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the WNT gene family. It encodes a protein showing 99% and 91% amino acid identity to the mouse and Xenopus Wnt7A proteins, respectively. Among members of the human WNT family, this protein is most similar to WNT7A protein (77.1% total amino acid identity). This gene may play important roles in the development and progression of gastric cancer, esophageal cancer, and pancreatic cancer.^[8]

Role in kidney

Wnt7b is a key paracrine signaling factor secreted by the ureteric epithelium that establishes the cortico-medullary axis of the mammalian kidney.^[9] Wnt7b is a signaling protein that plays a crucial role for many developmental processes including placental, lung, eye, dendrite, and bone formation along with kidney development. The primary role of Wnt7b is to establish the cortico-medullary axis of epithelial organization. The establishment of the cortico-medullary axis plays an essential role for the development of the medullary component of the kidney. Wnt7b regulates orientation of cell divisions in renal medullary collecting duct epithelium, in which is the major structure driving renal medulla formation. There are two interstitial regulators that are explicitly linked to medullary development; Pod1 which encodes a transcription factor expressed in the renal interstitium while p57Kip2 encodes a cyclin-dependent kinase inhibitor which is linked to Beckwith-Wiedemann syndrome. Pod1, p57Kip2 and integrin α3 (ITGA3) are three factors that are involved in renal medullary morphogenesis. The knockout of Pod1 results in no renal medullary formation while p57Kip2 and Itga3 knockouts resulted in a reduced renal medulla. Removal of Wnt7b activity leads to a failure of medullary development while other aspects of kidney development including ureteric branching, development of the renal cortex, and nephrogenesis are unaffected. The absence of renal medulla also affects the plane of epithelial cell division along with little proliferative growth of the loop of Henle. Wnt7b null allele will result in fatality due to the diminution of placental function leading to the failure to initiate organogenesis.^[9]

References

Further reading

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