TAFA5

Protein-coding gene in the species Homo sapiens
TAFA5
Identifiers
AliasesTAFA5, QLLK5208, TAFA-5, UNQ5208, family with sequence similarity 19 (chemokine (C-C motif)-like), member A5, family with sequence similarity 19 member A5, C-C motif chemokine like, TAFA chemokine like family member 5, FAM19A5
External IDsOMIM: 617499; MGI: 2146182; HomoloGene: 22888; GeneCards: TAFA5; OMA:TAFA5 - orthologs
Gene location (Human)
Chromosome 22 (human)
Chr.Chromosome 22 (human)[1]
Chromosome 22 (human)
Genomic location for TAFA5
Genomic location for TAFA5
Band22q13.32Start48,489,553 bp[1]
End48,850,912 bp[1]
Gene location (Mouse)
Chromosome 15 (mouse)
Chr.Chromosome 15 (mouse)[2]
Chromosome 15 (mouse)
Genomic location for TAFA5
Genomic location for TAFA5
Band15|15 E3Start87,428,500 bp[2]
End87,643,565 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • cerebellar vermis

  • tibial nerve

  • hypothalamus

  • amygdala

  • hippocampus proper

  • entorhinal cortex

  • Brodmann area 9

  • postcentral gyrus

  • right frontal lobe

  • superior frontal gyrus
Top expressed in
  • superior colliculus

  • central gray substance of midbrain

  • dorsal tegmental nucleus

  • lateral septal nucleus

  • nucleus of stria terminalis

  • anterior amygdaloid area

  • ventral tegmental area

  • inferior colliculus

  • dorsomedial hypothalamic nucleus

  • paraventricular nucleus of hypothalamus
More reference expression data
BioGPS
n/a
Gene ontology
Molecular function
  • cytokine activity
Cellular component
  • membrane
  • integral component of membrane
  • extracellular region
  • extracellular space
Biological process
  • regulation of signaling receptor activity
  • signal transduction
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

25817

106014

Ensembl

ENSG00000219438

ENSMUSG00000054863

UniProt

Q7Z5A7

Q91WE9

RefSeq (mRNA)

NM_015381
NM_001082967

NM_001252310
NM_134096

RefSeq (protein)

NP_001076436
NP_056196

NP_001239239
NP_598857

Location (UCSC)Chr 22: 48.49 – 48.85 MbChr 15: 87.43 – 87.64 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Chemokine-like protein TAFA-5 is a protein that in humans is encoded by the TAFA5 gene.[5][6]

This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to CCL3, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines, that act as regulators of immune and nervous cells.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000219438 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054863 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tom Tang Y, Emtage P, Funk WD, Hu T, Arterburn M, Park EE, Rupp F (Mar 2004). "TAFA: a novel secreted family with conserved cysteine residues and restricted expression in the brain". Genomics. 83 (4): 727–34. doi:10.1016/j.ygeno.2003.10.006. PMID 15028294.
  6. ^ a b "TAFA5 TAFA chemokine like family member 5 [ Homo sapiens (human) ]". National Center for Biotechnology Information. Retrieved 11 August 2019.

Further reading

  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
  • Clark HF, Gurney AL, Abaya E, et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
  • Yu W, Andersson B, Worley KC, et al. (1997). "Large-Scale Concatenation cDNA Sequencing". Genome Res. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
  • Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.