TAF6L

TAF6L
Identifiers
Aliases	TAF6L, PAF65A, TATA-box binding protein associated factor 6 like
External IDs	OMIM: 602946; MGI: 2444957; HomoloGene: 4728; GeneCards: TAF6L; OMA:TAF6L - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q12.3 Start 62,771,357 bp[1] End 62,787,342 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 A Start 8,751,851 bp[2] End 8,763,781 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of thyroid gland right lobe of liver apex of heart left lobe of thyroid gland anterior pituitary left uterine tube right ovary body of pancreas gastrocnemius muscle muscle of thigh Top expressed in saccule tail of embryo otic vesicle spermatid spermatocyte ventricular zone genital tubercle embryo yolk sac right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding transcription coactivator activity protein binding protein heterodimerization activity histone acetyltransferase activity DNA-binding transcription factor activity Cellular component histone deacetylase complex extracellular exosome nucleoplasm nucleus SAGA complex transcription factor TFIID complex SLIK (SAGA-like) complex Biological process regulation of transcription by RNA polymerase II chromatin remodeling regulation of transcription, DNA-templated regulation of DNA-binding transcription factor activity histone H3 acetylation transcription, DNA-templated DNA-templated transcription, initiation chromatin organization transcription by RNA polymerase II transcription initiation from RNA polymerase II promoter positive regulation of nucleic acid-templated transcription RNA polymerase II preinitiation complex assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10629 225895 Ensembl ENSG00000162227 ENSMUSG00000003680 UniProt Q9Y6J9 Q8R2K4 RefSeq (mRNA) NM_006473 NM_001177798 NM_146092 RefSeq (protein) NP_006464 NP_001171269 NP_666204 Location (UCSC) Chr 11: 62.77 – 62.79 Mb Chr 19: 8.75 – 8.76 Mb PubMed search [3] [4]
Wikidata
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TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L is an enzyme that in humans is encoded by the TAF6L gene.^[5][6]

Function

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation.^[6]

Interactions

TAF6L has been shown to interact with TAF9^[7] and Transcription initiation protein SPT3 homolog.^[7]

References

Further reading