Protein-coding gene in the species Homo sapiens
SLC26A6 |
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Identifiers |
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Aliases | SLC26A6, solute carrier family 26 member 6 |
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External IDs | OMIM: 610068; MGI: 2159728; HomoloGene: 99903; GeneCards: SLC26A6; OMA:SLC26A6 - orthologs |
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Gene location (Human) |
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| Chr. | Chromosome 3 (human)[1] |
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| Band | 3p21.31 | Start | 48,625,723 bp[1] |
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End | 48,635,493 bp[1] |
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Gene location (Mouse) |
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| Chr. | Chromosome 9 (mouse)[2] |
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| Band | 9|9 F2 | Start | 108,730,482 bp[2] |
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End | 108,742,117 bp[2] |
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RNA expression pattern |
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Bgee | Human | Mouse (ortholog) |
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Top expressed in | - popliteal artery
- ascending aorta
- oocyte
- rectum
- stromal cell of endometrium
- left coronary artery
- body of stomach
- right coronary artery
- secondary oocyte
- canal of the cervix
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| Top expressed in | - duodenum
- jejunum
- ileum
- yolk sac
- pancreas
- muscle tissue
- skeletal muscle tissue
- quadriceps femoris muscle
- secondary oocyte
- islet of Langerhans
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| More reference expression data |
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BioGPS | |
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Gene ontology |
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Molecular function | - PDZ domain binding
- formate transmembrane transporter activity
- chloride transmembrane transporter activity
- anion transmembrane transporter activity
- sulfate transmembrane transporter activity
- secondary active sulfate transmembrane transporter activity
- bicarbonate transmembrane transporter activity
- formate efflux transmembrane transporter activity
- oxalate transmembrane transporter activity
- protein binding
- efflux transmembrane transporter activity
- antiporter activity
- chloride channel activity
- inorganic anion exchanger activity
| Cellular component | - integral component of membrane
- membrane
- intracellular membrane-bounded organelle
- vesicle membrane
- plasma membrane
- integral component of plasma membrane
- chloride channel complex
- brush border membrane
- basolateral plasma membrane
- apical plasma membrane
- endoplasmic reticulum
- sperm midpiece
- cytoplasmic vesicle membrane
- cytoplasmic vesicle
- intracellular anatomical structure
- vesicle
| Biological process | - oxalic acid secretion
- mannitol transport
- oxalate transport
- formate transport
- intracellular pH elevation
- sulfate transport
- epithelial fluid transport
- angiotensin-activated signaling pathway
- regulation of membrane potential
- regulation of intracellular pH
- cellular response to fructose stimulus
- ion transport
- transepithelial chloride transport
- protein kinase C signaling
- anion transport
- transepithelial transport
- cellular response to interferon-gamma
- sperm capacitation
- intestinal absorption
- chloride transport
- positive regulation of dipeptide transmembrane transport
- cellular response to cAMP
- anion transmembrane transport
- sulfate transmembrane transport
- bicarbonate transport
- transmembrane transport
- chloride transmembrane transport
| Sources:Amigo / QuickGO |
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Orthologs |
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Species | Human | Mouse |
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Entrez | | |
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Ensembl | | |
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UniProt | | |
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RefSeq (mRNA) | NM_134426 NM_001040454 NM_001281732 NM_001281733 NM_022911
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NM_134263 |
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RefSeq (protein) | NP_001035544 NP_001268661 NP_001268662 NP_075062 NP_599025
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NP_602298 NP_001035544.1 |
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Location (UCSC) | Chr 3: 48.63 – 48.64 Mb | Chr 9: 108.73 – 108.74 Mb |
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PubMed search | [3] | [4] |
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Wikidata |
View/Edit Human | View/Edit Mouse |
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Solute carrier family 26 member 6 is a protein that in humans is encoded by the SLC26A6 gene.[5][6][7] It is an anion-exchanger expressed in the apical membrane of the kidney proximal tubule, the apical membranes of the duct cells in the pancreas, and the villi of the duodenum.[8]
This gene belongs to the solute carrier 26 family, whose members encode anion transporter proteins. This particular family member encodes a protein involved in transporting chloride, oxalate, sulfate and bicarbonate. Several alternatively spliced transcript variants of this gene, encoding distinct isoforms, have been described, but the full-length nature of some of these variants has not been determined.[7]
Associated diseases
Diseases associated with SLC26A6 include sialolithiasis and urolithiasis.[9]
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000225697 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023259 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Lohi H; Kujala M; Kerkela E; Saarialho-Kere U; Kestila M; Kere J (Jan 2001). "Mapping of five new putative anion transporter genes in human and characterization of SLC26A6, a candidate gene for pancreatic anion exchanger". Genomics. 70 (1): 102–12. doi:10.1006/geno.2000.6355. PMID 11087667.
- ^ Waldegger S; Moschen I; Ramirez A; Smith RJ; Ayadi H; Lang F; Kubisch C (Mar 2001). "Cloning and characterization of SLC26A6, a novel member of the solute carrier 26 gene family". Genomics. 72 (1): 43–50. doi:10.1006/geno.2000.6445. PMID 11247665.
- ^ a b "Entrez Gene: SLC26A6 solute carrier family 26, member 6".
- ^ Wang, Zhaohui; Tong Wang; Snezana Petrovic; Biguang Tuo; Brigitte Riederer; Sharon Barone; John N. Lorenz; Ursula Seidler; Peter S. Aronson; Manoocher Soleimani (April 2005). "Renal and intestinal transport defects in Slc26a6-null mice". American Journal of Physiology. Cell Physiology. 4. 288 (4): C957–C965. doi:10.1152/ajpcell.00505.2004. PMID 15574486. S2CID 23214608.
- ^ "SLC26A6 Gene - GeneCards | S26A6 Protein | S26A6 Antibody". www.genecards.org. Retrieved 2021-05-06.
Further reading
- Markovich D (2001). "Physiological roles and regulation of mammalian sulfate transporters". Physiol. Rev. 81 (4): 1499–533. doi:10.1152/physrev.2001.81.4.1499. PMID 11581495. S2CID 30942862.
- Ignatovich O, Tomlinson IM, Popov AV, et al. (2000). "Dominance of intrinsic genetic factors in shaping the human immunoglobulin Vlambda repertoire". J. Mol. Biol. 294 (2): 457–65. doi:10.1006/jmbi.1999.3243. PMID 10610771.
- Xie Q, Welch R, Mercado A, et al. (2002). "Molecular characterization of the murine Slc26a6 anion exchanger: functional comparison with Slc26a1". Am. J. Physiol. Renal Physiol. 283 (4): F826–38. doi:10.1152/ajprenal.00079.2002. PMID 12217875.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Chernova MN, Jiang L, Friedman DJ, et al. (2005). "Functional comparison of mouse slc26a6 anion exchanger with human SLC26A6 polypeptide variants: differences in anion selectivity, regulation, and electrogenicity". J. Biol. Chem. 280 (9): 8564–80. doi:10.1074/jbc.M411703200. PMID 15548529.
- Kujala M, Tienari J, Lohi H, et al. (2006). "SLC26A6 and SLC26A7 anion exchangers have a distinct distribution in human kidney". Nephron Exp. Nephrol. 101 (2): e50–8. doi:10.1159/000086345. PMID 15956810. S2CID 26671784.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Shcheynikov N, Wang Y, Park M, et al. (2006). "Coupling modes and stoichiometry of Cl-/HCO3- exchange by slc26a3 and slc26a6". J. Gen. Physiol. 127 (5): 511–24. doi:10.1085/jgp.200509392. PMC 2151520. PMID 16606687.
- Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
- Alper SL, Stewart AK, Chernova MN, et al. (2007). "Anion exchangers in flux: functional differences between human and mouse SLC26A6 polypeptides". Epithelial Anion Transport in Health and Disease: The Role of the SLC26 Transporters Family. Novartis Foundation Symposia. Vol. 273. pp. 107–19, discussion 119–25, 261–4. doi:10.1002/0470029579.ch8. ISBN 9780470016244. PMID 17120764.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
By group |
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SLC1–10 |
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(1): | |
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(2): | |
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(3): | |
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(4): | |
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(5): | |
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(6): | |
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(7): | |
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(8): | |
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(9): | |
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(10): | |
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| SLC11–20 |
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(11): | - proton coupled metal ion transporter
|
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(12): | |
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(13): | - human Na+-sulfate/carboxylate cotransporter
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(14): | |
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(15): | - proton oligopeptide cotransporter
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(16): | - monocarboxylate transporter
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(17): | |
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(18): | |
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(19): | |
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(20): | - type III Na+-phosphate cotransporter
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| SLC21–30 |
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(21): | |
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(22): | |
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(23): | - Na+-dependent ascorbic acid transporter
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(24): | |
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(25): | |
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(26): | - multifunctional anion exchanger
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(27): | |
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(28): | - Na+-coupled nucleoside transport (SLC28A1
|
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(29): | - facilitative nucleoside transporter
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(30): | |
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| SLC31–40 |
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(31): | |
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(32): | |
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(33): | |
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(34): | - type II Na+-phosphate cotransporter
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(35): | - nucleoside-sugar transporter
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-
-
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- SLC35E1
- SLC35E2
- SLC35E3
- SLC35E4
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(36): | |
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(37): | - sugar-phosphate/phosphate exchanger
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(38): | - System A & N, sodium-coupled neutral amino-acid transporter
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(39): | |
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(40): | - basolateral iron transporter
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| SLC41–48 |
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(41): | |
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(42): | |
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(43): | - Na+-independent, system-L like amino-acid transporter
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(44): | |
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(45): | - Putative sugar transporter
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(46): | |
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(47): | |
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(48): | |
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see also solute carrier disorders |
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