SC-17599
Chemical compound
- In general: legal
- 6-[(dimethylamino)methyl]-3-ethoxy-21-fluoro-20-oxopregna-3,5-dien-17-yl acetate
- 10436424
- 8611848 N
- DTXSID301018437
- Interactive image
- FCC(=O)[C@@]1(OC(=O)C)CC[C@H]2[C@H]4[C@H](CC[C@]12C)[C@@]3(C(\C=C(\OCC)CC3)=C(\CN(C)C)C4)C
InChI
- InChI=1S/C28H42FNO4/c1-7-33-20-8-11-26(3)22-9-12-27(4)23(10-13-28(27,25(32)16-29)34-18(2)31)21(22)14-19(17-30(5)6)24(26)15-20/h15,21-23H,7-14,16-17H2,1-6H3/t21-,22+,23+,26-,27+,28+/m1/s1 N
- Key:ZPVGJKVIJYUOCI-ORZTVLAMSA-N N
SC-17599 is a steroid derivative drug discovered in 1968 which acts as a selective μ-opioid receptor agonist, with little or no affinity for the δ-opioid or κ-opioid receptors. It is an active analgesic in vivo, more potent than codeine or pethidine but slightly less potent than morphine, [1] and produces similar effects to morphine in animals but with less sedation[2][3]
See also
- Cyproterone acetate
References
- ^ Craig CR (1968). "Analgetic Activity and Other Pharmacological Properties of a Steroid; 17α-acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxypregna-3,5-dien-20-one Hydrochloride (SC17599)". Journal of Pharmacology and Experimental Therapeutics. 164 (2): 371–379. PMID 5699098.
- ^ McFadyen IJ, Houshyar H, Liu-Chen LY, Woods JH, Traynor JR (October 2000). "The steroid 17alpha-acetoxy-6-dimethylaminomethyl-21-fluoro-3-ethoxy-pregna-3, 5-dien-20-one (SC17599) is a selective mu-opioid agonist: implications for the mu-opioid pharmacophore". Molecular Pharmacology. 58 (4): 669–76. doi:10.1124/mol.58.4.669. PMID 10999935.
- ^ Houshyar H, Mc Fadyen IJ, Woods JH, Traynor JR (April 2000). "Antinociceptive and other behavioral effects of the steroid SC17599 are mediated by the mu-opioid receptor". European Journal of Pharmacology. 395 (2): 121–8. doi:10.1016/s0014-2999(00)00176-x. PMID 10794817.
- v
- t
- e
(MOR)
(DOR)
(KOR)
(NOP)
Agonists |
|
---|---|
Antagonists |
|
- Enkephalinase inhibitors: Amastatin
- BL-2401
- Candoxatril
- D -Phenylalanine
- Dexecadotril (retorphan)
- Ecadotril (sinorphan)
- Kelatorphan
- Racecadotril (acetorphan)
- RB-101
- RB-120
- RB-3007
- Opiorphan
- Selank
- Semax
- Spinorphin
- Thiorphan
- Tynorphin
- Ubenimex (bestatin)
- Propeptides: β-Lipotropin (proendorphin)
- Prodynorphin
- Proenkephalin
- Pronociceptin
- Proopiomelanocortin (POMC)
- Others: Kyotorphin (met-enkephalin releaser/degradation stabilizer)
This analgesic-related article is a stub. You can help Wikipedia by expanding it. |
- v
- t
- e