Rescinnamine
Chemical compound
- C02AA01 (WHO)
- In general: ℞ (Prescription only)
- methyl (3β,16β,17α,18β,20α)-11,17-dimethoxy-18-{[(2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoyl]oxy}yohimban-16-carboxylate
- 24815-24-5 Y
- 5280954
- 7098
- DB01180 Y
- 4444446 Y
- Q6W1F7DJ2D
- D00198 Y
- CHEBI:28572 Y
- ChEMBL1668 Y
- DTXSID3023554
- Interactive image
- [H][C@]26C[C@@H](OC(=O)/C=C/c1cc(OC)c(OC)c(OC)c1)[C@H](OC)[C@@H](C(=O)OC)[C@@]2([H])C[C@]5([H])c4[nH]c3cc(OC)ccc3c4CCN5C6
InChI
- InChI=1S/C35H42N2O9/c1-40-21-8-9-22-23-11-12-37-18-20-15-29(46-30(38)10-7-19-13-27(41-2)33(43-4)28(14-19)42-3)34(44-5)31(35(39)45-6)24(20)17-26(37)32(23)36-25(22)16-21/h7-10,13-14,16,20,24,26,29,31,34,36H,11-12,15,17-18H2,1-6H3/b10-7+/t20-,24+,26-,29-,31+,34+/m1/s1 Y
- Key:SZLZWPPUNLXJEA-QEGASFHISA-N Y
Rescinnamine, known by the brand names Moderil, Cinnasil, and Anaprel, is an angiotensin-converting enzyme inhibitor used as an antihypertensive drug.
It is a vinca alkaloid obtained from Rauvolfia serpentina[1] and other species of Rauvolfia.[2]
References
- ^ FIFE R, MACLAURIN JC, WRIGHT JH (December 1960). "Rescinnamine in treatment of hypertension in hospital clinic and in general practice". British Medical Journal. 2 (5216): 1848–50. doi:10.1136/bmj.2.5216.1848. PMC 2098607. PMID 13699407.
- ^ Balsevich J, Constabel F, Kurz WG (1982). "Alkaloids of Vinca major cv. Variegata". Planta Med. 44 (2): 91–3. doi:10.1055/s-2007-971409. PMID 17402086.
- v
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- e
("-pril")
- Sulfhydryl-containing: Captopril
- Rentiapril
- Zofenopril
- Dicarboxylate-containing: Enalapril#
- Benazepril
- Cilazapril
- Delapril
- Imidapril
- Lisinopril (+amlodipine, +HCT)
- Moexipril
- Perindopril (+indapamide)
- Quinapril (+HCT)
- Ramipril
- Spirapril
- Temocapril
- Trandolapril
- Phosphonate-containing: Ceronapril
- Fosinopril (+HCT)
- Other/ungrouped: Alacepril
("-sartan")
("-kiren")
- Gemopatrilat
- Ilepatril
- Omapatrilat
- Sampatrilat
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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