Protein-coding gene in the species Homo sapiens
| PPP1CB |
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| Identifiers |
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| Aliases | PPP1CB, HEL-S-80p, PP-1B, PP1B, PP1beta, PPP1CD, protein phosphatase 1 catalytic subunit beta, NSLH2, PPP1beta, PP1c, MP |
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| External IDs | OMIM: 600590; MGI: 104871; HomoloGene: 37659; GeneCards: PPP1CB; OMA:PPP1CB - orthologs |
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| Gene location (Human) |
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 | | Chr. | Chromosome 2 (human)[1] |
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| | Band | 2p23.2 | Start | 28,751,640 bp[1] |
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| End | 28,802,940 bp[1] |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 5 (mouse)[2] |
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| | Band | 5|5 B1 | Start | 32,616,187 bp[2] |
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| End | 32,674,777 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - Achilles tendon
- amniotic fluid
- buccal mucosa cell
- ventricular zone
- Descending thoracic aorta
- popliteal artery
- tibial arteries
- ascending aorta
- caput epididymis
- ganglionic eminence
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| | Top expressed in | - blood
- Gonadal ridge
- atrium
- lobe of cerebellum
- pineal gland
- olfactory tubercle
- ventral tegmental area
- medial vestibular nucleus
- cerebellar vermis
- parotid gland
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| | More reference expression data |
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| BioGPS | |
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| Gene ontology |
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| Molecular function | - phosphoprotein phosphatase activity
- myosin phosphatase activity
- phosphatase activity
- protein serine/threonine phosphatase activity
- metal ion binding
- myosin-light-chain-phosphatase activity
- protein binding
- protein kinase binding
- hydrolase activity
| | Cellular component | - cytoplasm
- cytosol
- focal adhesion
- nucleoplasm
- protein phosphatase type 1 complex
- glycogen granule
- PTW/PP1 phosphatase complex
- nucleolus
- extracellular exosome
- nucleus
- plasma membrane
| | Biological process | - rhythmic process
- protein dephosphorylation
- circadian regulation of gene expression
- cell division
- regulation of cell adhesion
- G2/M transition of mitotic cell cycle
- regulation of circadian rhythm
- glycogen metabolic process
- regulation of glycogen biosynthetic process
- cell cycle
- regulation of glycogen catabolic process
- entrainment of circadian clock by photoperiod
- carbohydrate metabolic process
| | Sources:Amigo / QuickGO |
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| Orthologs |
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| Species | Human | Mouse |
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| Entrez | | |
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| Ensembl | | |
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| UniProt | | |
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| RefSeq (mRNA) | |
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NM_206877
NM_002709
NM_206876 |
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| RefSeq (protein) | | |
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| Location (UCSC) | Chr 2: 28.75 – 28.8 Mb | Chr 5: 32.62 – 32.67 Mb |
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| PubMed search | [3] | [4] |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Serine/threonine-protein phosphatase PP1-beta catalytic subunit is an enzyme that in humans is encoded by the PPP1CB gene.[5]
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Mouse studies suggest that PP1 functions as a suppressor of learning and memory. Two alternatively spliced transcript variants encoding distinct isoforms have been observed.[6]
Interactions
PPP1CB has been shown to interact with PPP1R15A,[7][8] Nucleolin,[9] SMARCB1[7] and PPP1R9B.[10]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000213639 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000014956 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Barker HM, Brewis ND, Street AJ, Spurr NK, Cohen PT (March 1994). "Three genes for protein phosphatase 1 map to different human chromosomes: sequence, expression and gene localisation of protein serine/threonine phosphatase 1 beta (PPP1CB)". Biochim Biophys Acta. 1220 (2): 212–8. doi:10.1016/0167-4889(94)90138-4. PMID 8312365.
- ^ "Entrez Gene: PPP1CB protein phosphatase 1, catalytic subunit, beta isoform".
- ^ a b Wu DY, Tkachuck Douglas C, Roberson Rachel S, Schubach William H (August 2002). "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and modulates GADD34-bound protein phosphatase-1 activity". J. Biol. Chem. 277 (31): 27706–15. doi:10.1074/jbc.M200955200. ISSN 0021-9258. PMID 12016208.
- ^ Connor JH, Weiser D C, Li S, Hallenbeck J M, Shenolikar S (October 2001). "Growth arrest and DNA damage-inducible protein GADD34 assembles a novel signaling complex containing protein phosphatase 1 and inhibitor 1". Mol. Cell. Biol. 21 (20): 6841–50. doi:10.1128/MCB.21.20.6841-6850.2001. ISSN 0270-7306. PMC 99861. PMID 11564868.
- ^ Morimoto H, Okamura Hirohiko, Haneji Tatsuji (September 2002). "Interaction of protein phosphatase 1 delta with nucleolin in human osteoblastic cells". J. Histochem. Cytochem. 50 (9): 1187–93. doi:10.1177/002215540205000905. ISSN 0022-1554. PMID 12185196.
- ^ Hsieh-Wilson LC, Allen P B, Watanabe T, Nairn A C, Greengard P (April 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". Biochemistry. 38 (14): 4365–73. doi:10.1021/bi982900m. ISSN 0006-2960. PMID 10194355.
Further reading
- Prochazka M, Mochizuki H, Baier LJ, et al. (1995). "Molecular and linkage analysis of type-1 protein phosphatase catalytic beta-subunit gene: lack of evidence for its major role in insulin resistance in Pima Indians". Diabetologia. 38 (4): 461–6. doi:10.1007/BF00410284. PMID 7796987.
- Saadat M, Kakinoki Y, Mizuno Y, et al. (1995). "Chromosomal localization of human, rat, and mouse protein phosphatase type 1 beta catalytic subunit genes (PPP1CB) by fluorescence in situ hybridization". Jpn. J. Genet. 69 (6): 697–700. doi:10.1266/jjg.69.697. PMID 7857673.
- Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
- Kawabe T, Muslin AJ, Korsmeyer SJ (1997). "HOX11 interacts with protein phosphatases PP2A and PP1 and disrupts a G2/M cell-cycle checkpoint". Nature. 385 (6615): 454–8. Bibcode:1997Natur.385..454K. doi:10.1038/385454a0. PMID 9009195. S2CID 608633.
- Fujioka M, Takahashi N, Odai H, et al. (1998). "A new isoform of human myosin phosphatase targeting/regulatory subunit (MYPT2): cDNA cloning, tissue expression, and chromosomal mapping". Genomics. 49 (1): 59–68. doi:10.1006/geno.1998.5222. PMID 9570949.
- Verin AD, Csortos C, Durbin SD, et al. (2000). "Characterization of the protein phosphatase 1 catalytic subunit in endothelium: involvement in contractile responses". J. Cell. Biochem. 79 (1): 113–25. doi:10.1002/1097-4644(2000)79:1<113::AID-JCB110>3.0.CO;2-9. PMID 10906760. S2CID 42857803.
- Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
- Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
- Tan I, Ng CH, Lim L, Leung T (2001). "Phosphorylation of a novel myosin binding subunit of protein phosphatase 1 reveals a conserved mechanism in the regulation of actin cytoskeleton". J. Biol. Chem. 276 (24): 21209–16. doi:10.1074/jbc.M102615200. PMID 11399775.
- Fresu M, Bianchi M, Parsons JT, Villa-Moruzzi E (2001). "Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase". Biochem. J. 358 (Pt 2): 407–14. doi:10.1042/0264-6021:3580407. PMC 1222073. PMID 11513739.
- Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi:10.1016/S0960-9822(01)00650-9. PMID 11790298. S2CID 14132033.
- Bharucha DC, Zhou M, Nekhai S, et al. (2002). "A protein phosphatase from human T cells augments tat transactivation of the human immunodeficiency virus type 1 long-terminal repeat". Virology. 296 (1): 6–16. doi:10.1006/viro.2002.1438. PMID 12036313.
- Ceulemans H, Vulsteke V, De Maeyer M, et al. (2003). "Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1". J. Biol. Chem. 277 (49): 47331–7. doi:10.1074/jbc.M206838200. PMID 12226088.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Gevaert K, Goethals M, Martens L, et al. (2004). "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. doi:10.1038/nbt810. PMID 12665801. S2CID 23783563.
- Galey D, Becker K, Haughey N, et al. (2003). "Differential transcriptional regulation by human immunodeficiency virus type 1 and gp120 in human astrocytes". J. Neurovirol. 9 (3): 358–71. doi:10.1080/13550280390201119. PMID 12775419. S2CID 22016092.
- Ammosova T, Jerebtsova M, Beullens M, et al. (2003). "Nuclear protein phosphatase-1 regulates HIV-1 transcription". J. Biol. Chem. 278 (34): 32189–94. doi:10.1074/jbc.M300521200. PMID 12788939.
- Llorian M, Beullens M, Andrés I, et al. (2004). "SIPP1, a novel pre-mRNA splicing factor and interactor of protein phosphatase-1". Biochem. J. 378 (Pt 1): 229–38. doi:10.1042/BJ20030950. PMC 1223944. PMID 14640981.
- Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216. S2CID 11683986.
PDB gallery
-
1s70: Complex between protein ser/thr phosphatase-1 (delta) and the myosin phosphatase targeting subunit 1 (MYPT1) -
1u32: Crystal structure of a Protein Phosphatase-1: Calcineurin Hybrid Bound to Okadaic Acid |
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1s70: Complex between protein ser/thr phosphatase-1 (delta) and the myosin phosphatase targeting subunit 1 (MYPT1)
1u32: Crystal structure of a Protein Phosphatase-1: Calcineurin Hybrid Bound to Okadaic Acid
