MRPS11

Protein-coding gene in the species Homo sapiens
MRPS11
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

3J9M

Identifiers
AliasesMRPS11, HCC-2, MRP-S11, S11mt, mitochondrial ribosomal protein S11
External IDsOMIM: 611977; MGI: 1915244; HomoloGene: 32554; GeneCards: MRPS11; OMA:MRPS11 - orthologs
Gene location (Human)
Chromosome 15 (human)
Chr.Chromosome 15 (human)[1]
Chromosome 15 (human)
Genomic location for MRPS11
Genomic location for MRPS11
Band15q25.3Start88,467,453 bp[1]
End88,480,776 bp[1]
Gene location (Mouse)
Chromosome 7 (mouse)
Chr.Chromosome 7 (mouse)[2]
Chromosome 7 (mouse)
Genomic location for MRPS11
Genomic location for MRPS11
Band7|7 D2Start78,432,867 bp[2]
End78,442,737 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • apex of heart

  • mucosa of transverse colon

  • left ventricle

  • left adrenal gland

  • right adrenal gland

  • right adrenal cortex

  • left adrenal cortex

  • right lobe of thyroid gland

  • right auricle

  • muscle of thigh
Top expressed in
  • spermatid

  • blastocyst

  • embryo

  • spermatocyte

  • embryo

  • right kidney

  • morula

  • adrenal gland

  • sternocleidomastoid muscle

  • yolk sac
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • structural constituent of ribosome
  • mRNA 5'-UTR binding
  • small ribosomal subunit rRNA binding
  • RNA binding
Cellular component
  • mitochondrial inner membrane
  • ribosome
  • mitochondrion
  • mitochondrial small ribosomal subunit
Biological process
  • ribosomal small subunit assembly
  • maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
  • mitochondrial translational elongation
  • mitochondrial translational termination
  • protein biosynthesis
  • mitochondrial translation
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

64963

67994

Ensembl

ENSG00000181991

ENSMUSG00000030611

UniProt

P82912

Q9DCA2

RefSeq (mRNA)
NM_022839
NM_176805
NM_001321970
NM_001321972
NM_001321973

NM_001321974
NM_001321976

NM_026498
NM_001360702

RefSeq (protein)
NP_001308899
NP_001308901
NP_001308902
NP_001308903
NP_001308905

NP_073750
NP_789775

n/a

Location (UCSC)Chr 15: 88.47 – 88.48 MbChr 7: 78.43 – 78.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

28S ribosomal protein S11, mitochondrial is a protein that in humans is encoded by the MRPS11 gene.[5][6]

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that contains a high level of sequence similarity with ribosomal protein S11P family members.[6]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000181991 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000030611 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Suzuki T, Terasaki M, Takemoto-Hori C, Hanada T, Ueda T, Wada A, Watanabe K (Aug 2001). "Proteomic analysis of the mammalian mitochondrial ribosome. Identification of protein components in the 28 S small subunit". J Biol Chem. 276 (35): 33181–95. doi:10.1074/jbc.M103236200. PMID 11402041.
  6. ^ a b "Entrez Gene: MRPS11 mitochondrial ribosomal protein S11".

Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
  • Cavdar Koc E, Burkhart W, Blackburn K, et al. (2001). "The small subunit of the mammalian mitochondrial ribosome. Identification of the full complement of ribosomal proteins present". J. Biol. Chem. 276 (22): 19363–74. CiteSeerX 10.1.1.501.8919. doi:10.1074/jbc.M100727200. PMID 11279123.
  • Kenmochi N, Suzuki T, Uechi T, et al. (2001). "The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders". Genomics. 77 (1–2): 65–70. doi:10.1006/geno.2001.6622. PMID 11543634.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Zhang Z, Gerstein M (2003). "Identification and characterization of over 100 mitochondrial ribosomal protein pseudogenes in the human genome". Genomics. 81 (5): 468–80. doi:10.1016/S0888-7543(03)00004-1. PMID 12706105.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Ishiguchi H, Izumi H, Torigoe T, et al. (2004). "ZNF143 activates gene expression in response to DNA damage and binds to cisplatin-modified DNA". Int. J. Cancer. 111 (6): 900–9. doi:10.1002/ijc.20358. PMID 15300802. S2CID 37308382.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

  • Overview of all the structural information available in the PDB for UniProt: P82912 (28S ribosomal protein S11, mitochondrial) at the PDBe-KB.


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Proteins
Initiation factor
Bacterial
Mitochondrial
Archaeal
  • aIF1
  • aIF2
  • aIF5
  • aIF6
Eukaryotic
eIF1
eIF2
eIF3
eIF4
eIF5
eIF6
Elongation factor
Bacterial/​Mitochondrial
Archaeal/​Eukaryotic
Release factor
Ribosomal Proteins
Cytoplasmic
60S subunit
40S subunit
Mitochondrial
39S subunit
28S subunit
Other concepts
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