Lofendazam
Chemical compound
- none
- 8-chloro-1-phenyl-1,3,4,5-tetrahydro- 2H-1,5-benzodiazepin- 2-one
- 29176-29-2 Y
- 71709
- 64759 Y
- V7O53S50SN
- DTXSID30183436
- Interactive image
- Clc3ccc1c(N(C(=O)CCN1)c2ccccc2)c3
InChI
- InChI=1S/C15H13ClN2O/c16-11-6-7-13-14(10-11)18(15(19)8-9-17-13)12-4-2-1-3-5-12/h1-7,10,17H,8-9H2 Y
- Key:IUJQOUHDFKALCY-UHFFFAOYSA-N Y
Lofendazam[1] is an organic molecule which is a benzodiazepine derivative. Lofendazam is a 1,5-benzodiazepine, with the nitrogen atoms located at positions 1 and 5 of the diazepine ring; therefore, lofendazam is most closely related to other 1,5-benzodiazepines such as clobazam.[2][3]
Lofendazam as a human pharmaceutical has sedative and anxiolytic effects similar to those produced by other benzodiazepine derivatives. It is an active metabolite of another benzodiazepine, arfendazam.[4]
See also
- Benzodiazepine
- Arfendazam
- Clobazam
References
- ^ DE 1929656
- ^ Malik F, Hasan M, Khan KM, Perveen S, Snatzke G, Duddeck H, Voelter W (1995). "Syntheses and CD studies of optically active substituted 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-ones". Liebigs Annalen der Chemie. 1995 (10): 1861–1869. doi:10.1002/jlac.1995199510261.
- ^ Aversa MC, Giannetto P, Romeo G, Ficarra P, Vigorita MG (1981). "Nuclear magnetic resonance spectra of psychotherapeutic agents. V* - conformational analysis of 1,3,4,5-tetrahydro-2H-1,5-benzodiazepin-2-ones". Organic Magnetic Resonance. 15 (4): 394–398. doi:10.1002/mrc.1270150414.
- ^ Adrien J, Albani F, Baruzzi A, Berger M, Bixler EO, Borbeley AA, Dikeos DG, Drucker-Colin R, Montero RF, Hishikawa Y, Inoue S (11 December 1995). The Pharmacology of Sleep. Springer. ISBN 978-3-540-58961-7.
- v
- t
- e
- 2-Oxoquazepam
- 3-Hydroxyphenazepam
- Bromazepam
- BMS-906024*
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- Chlordiazepoxide
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- Lufuradom*
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- QH-II-66
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- RO4491533*
- Ro05-4082
- Ro5-4864*
- Ro07-5220
- Ro07-9749
- Ro20-8065
- Ro20-8552
- SH-I-048A
- Sulazepam
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- Tifluadom*
- Timelotem*
- Tolufazepam
- Triflunordazepam
- Tuclazepam
- Uldazepam
- Arfendazam
- Clobazam
- CP-1414S
- Lofendazam
- Triflubazam
* atypical activity profile (not GABAA receptor ligands)