FOXN1

FOXN1
Identifiers
Aliases	FOXN1, FKHL20, RONU, WHN, forkhead box N1, TIDAND, TLIND
External IDs	OMIM: 600838; MGI: 102949; HomoloGene: 2664; GeneCards: FOXN1; OMA:FOXN1 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q11.2 Start 28,506,243 bp[1] End 28,538,900 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B5|11 46.74 cM Start 78,248,403 bp[2] End 78,277,384 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gingival epithelium skin of thigh skin of abdomen human penis skin of hip vulva nipple oral cavity mucosa of pharynx vagina Top expressed in hair outer root sheath of hair follicle cortex of hair lip filiform papilla thymus skin of back skin of abdomen morula embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process hair follicle development defense response nail development regulation of transcription, DNA-templated blood vessel morphogenesis thymus epithelium morphogenesis thymus development regulation of transcription by RNA polymerase II lymphocyte homeostasis positive regulation of hair follicle development epithelial cell proliferation transcription by RNA polymerase II transcription, DNA-templated regulation of positive thymic T cell selection keratinocyte differentiation lymphoid lineage cell migration into thymus T cell homeostasis multicellular organism development regulation of T cell differentiation in thymus epidermis development animal organ morphogenesis regulation of gene expression cell population proliferation T cell lineage commitment positive regulation of epithelial cell differentiation cell differentiation positive regulation of transcription by RNA polymerase II hemopoiesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8456 15218 Ensembl ENSG00000109101 ENSMUSG00000002057 UniProt O15353 Q61575 RefSeq (mRNA) NM_003593 NM_001369369 NM_001277290 NM_008238 RefSeq (protein) NP_003584 NP_001356298 NP_001264219 NP_032264 Location (UCSC) Chr 17: 28.51 – 28.54 Mb Chr 11: 78.25 – 78.28 Mb PubMed search [3] [4]
Wikidata
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Forkhead box protein N1 is a protein that in humans is encoded by the FOXN1 gene.^[5][6]

Function

Mutations in the winged-helix transcription factor gene at the nude locus in mice and rats produce the pleiotropic phenotype of hairlessness and athymia, resulting in a severely compromised immune system. This gene is orthologous to the mouse and rat genes and encodes a similar DNA-binding transcription factor that is thought to regulate keratin gene expression. A mutation in this gene has been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing in the 5' UTR of this gene has been observed.^[6] In the chick embryo, the FOXN1 gene is expressed in the developing thymus, claws and feathers. The expression of FOXN1 in feathers and claws indicates that it may regulate the feather outgrowth. In feather and claws, FOXN1 can potentially regulate expression of keratins similar to mammalian orthologs. ^[7] In thymic epithelial cells, FOXN1 has been shown to bind to and regulate genes involved in T-cell maturation and antigen presentation.^[8]

References

Further reading

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