DGKD

Protein-coding gene in the species Homo sapiens

DGKD

Available structures

PDB

Ortholog search: PDBe RCSB

List of PDB id codes
1R79, 3BQ7

Identifiers

Aliases

DGKD, DGKdelta, dgkd-2, diacylglycerol kinase delta, DGK-delta

External IDs

OMIM: 601826; MGI: 2138334; HomoloGene: 100054; GeneCards: DGKD; OMA:DGKD - orthologs

Gene location (Human)

Chr.	Chromosome 2 (human)^[1]

Band	2q37.1	Start	233,354,494 bp^[1]
Band	2q37.1	End	233,472,104 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 D	Start	87,781,009 bp^[2]
Band	1\|1 D	End	87,872,902 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

body of stomach

cerebellar hemisphere

right hemisphere of cerebellum

granulocyte

gastrocnemius muscle

bone marrow

skeletal muscle tissue

blood

fundus

bone marrow cells

Top expressed in

spermatocyte

thymus

spermatid

granulocyte

brown adipose tissue

neural layer of retina

subcutaneous adipose tissue

mesenteric lymph nodes

cerebellum

lobe of cerebellum

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity nucleotide binding diacylglycerol kinase activity metal ion binding kinase activity protein binding diacylglycerol binding ATP binding NAD+ kinase activity identical protein binding protein homodimerization activity protein heterodimerization activity
Cellular component	cytoplasm membrane plasma membrane nucleus cytosol cytoplasmic vesicle
Biological process	intracellular signal transduction endocytosis epidermal growth factor receptor signaling pathway phosphorylation response to organic substance platelet activation multicellular organism development cell growth protein kinase C-activating G protein-coupled receptor signaling pathway diacylglycerol metabolic process protein transport second-messenger-mediated signaling protein homooligomerization lipid phosphorylation metabolism signal transduction glycerolipid metabolic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


8527


227333

Ensembl


ENSG00000077044 ENSG00000280873


ENSMUSG00000070738

UniProt


Q16760


E9PUQ8

RefSeq (mRNA)


NM_003648 NM_152879 NM_001377259


NM_177646

RefSeq (protein)


NP_003639 NP_690618 NP_001364188


NP_808314

Location (UCSC)

Chr 2: 233.35 – 233.47 Mb

Chr 1: 87.78 – 87.87 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Diacylglycerol kinase delta is an enzyme that in humans is encoded by the DGKD gene.^[5]^[6]^[7]

This gene encodes a cytoplasmic enzyme that phosphorylates diacylglycerol to produce phosphatidic acid. Diacylglycerol and phosphatidic acid are two lipids that act as second messengers in signaling cascades. Their cellular concentrations are regulated by the encoded protein, and so it is thought to play an important role in cellular signal transduction. Alternative splicing results in two transcript variants encoding different isoforms.^[7]

References

^ ^a ^b ^c ENSG00000280873 GRCh38: Ensembl release 89: ENSG00000077044, ENSG00000280873 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000070738 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Sakane F, Imai S, Kai M, Wada I, Kanoh H (Jun 1996). "Molecular cloning of a novel diacylglycerol kinase isozyme with a pleckstrin homology domain and a C-terminal tail similar to those of the EPH family of protein-tyrosine kinases". J Biol Chem. 271 (14): 8394–401. doi:10.1074/jbc.271.14.8394. PMID 8626538.
^ Murakami T, Sakane F, Imai S, Houkin K, Kanoh H (Sep 2003). "Identification and characterization of two splice variants of human diacylglycerol kinase eta". J Biol Chem. 278 (36): 34364–72. doi:10.1074/jbc.M301542200. PMID 12810723.
^ ^a ^b "Entrez Gene: DGKD diacylglycerol kinase, delta 130kDa".

Nagase T, Seki N, Tanaka A, et al. (1996). "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1". DNA Res. 2 (4): 167–74, 199–210. CiteSeerX 10.1.1.333.6945. doi:10.1093/dnares/2.4.167. PMID 8590280.
Bregoli L, Baldassare JJ, Raben DM (2001). "Nuclear diacylglycerol kinase-theta is activated in response to alpha-thrombin". J. Biol. Chem. 276 (26): 23288–95. doi:10.1074/jbc.M101501200. PMID 11309392.
Nagaya H, Wada I, Jia YJ, Kanoh H (2002). "Diacylglycerol kinase delta suppresses ER-to-Golgi traffic via its SAM and PH domains". Mol. Biol. Cell. 13 (1): 302–16. doi:10.1091/mbc.01-05-0255. PMC 65090. PMID 11809841.
Imai S, Sakane F, Kanoh H (2002). "Phorbol ester-regulated oligomerization of diacylglycerol kinase delta linked to its phosphorylation and translocation". J. Biol. Chem. 277 (38): 35323–32. doi:10.1074/jbc.M202035200. PMID 12084710.
Sakane F, Imai S, Yamada K, et al. (2003). "Alternative splicing of the human diacylglycerol kinase delta gene generates two isoforms differing in their expression patterns and in regulatory functions". J. Biol. Chem. 277 (45): 43519–26. doi:10.1074/jbc.M206895200. PMID 12200442.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Imai S, Kai M, Yamada K, et al. (2005). "The plasma membrane translocation of diacylglycerol kinase delta1 is negatively regulated by conventional protein kinase C-dependent phosphorylation at Ser-22 and Ser-26 within the pleckstrin homology domain". Biochem. J. 382 (Pt 3): 957–66. doi:10.1042/BJ20040681. PMC 1133971. PMID 15228384.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Leach NT, Sun Y, Michaud S, et al. (2007). "Disruption of diacylglycerol kinase delta (DGKD) associated with seizures in humans and mice". Am. J. Hum. Genet. 80 (4): 792–9. doi:10.1086/513019. PMC 1852716. PMID 17357084.