CDS1 (gene)

Protein-coding gene in the species Homo sapiens

CDS1

Identifiers

Aliases

CDS1, CDS, CDP-diacylglycerol synthase 1, CDS 1

External IDs

OMIM: 603548; MGI: 1921846; HomoloGene: 68173; GeneCards: CDS1; OMA:CDS1 - orthologs

Gene location (Human)

Chr.	Chromosome 4 (human)^[1]

Band	4q21.23	Start	84,583,127 bp^[1]
Band	4q21.23	End	84,651,334 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 5 (mouse)^[2]

Band	5\|5 E5	Start	101,912,996 bp^[2]
Band	5\|5 E5	End	101,971,724 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

bronchial epithelial cell

secondary oocyte

caput epididymis

amniotic fluid

jejunal mucosa

mucosa of paranasal sinus

corpus epididymis

middle temporal gyrus

nasal epithelium

Brodmann area 23

Top expressed in

transitional epithelium of urinary bladder

neural layer of retina

jejunum

nasal epithelium

olfactory epithelium

ileum

retinal pigment epithelium

vestibular membrane of cochlear duct

otolith organ

utricle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	transferase activity, transferring phosphorus-containing groups nucleotidyltransferase activity diacylglycerol cholinephosphotransferase activity transferase activity phosphatidate cytidylyltransferase activity
Cellular component	membrane integral component of membrane endoplasmic reticulum endoplasmic reticulum membrane
Biological process	phototransduction phospholipid biosynthetic process phosphatidylglycerol biosynthetic process CDP-diacylglycerol biosynthetic process lipid metabolism signal transduction phosphatidylinositol biosynthetic process CDP-choline pathway
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


1040


74596

Ensembl


ENSG00000163624


ENSMUSG00000029330

UniProt


Q92903


P98191

RefSeq (mRNA)


NM_001263


NM_173370

RefSeq (protein)


NP_001254


NP_775546

Location (UCSC)

Chr 4: 84.58 – 84.65 Mb

Chr 5: 101.91 – 101.97 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Phosphatidate cytidylyltransferase 1 is an enzyme that in humans is encoded by the CDS1 gene.^[5]^[6]^[7]

Function

Breakdown products of phosphoinositides are ubiquitous second messengers that function downstream of many G protein-coupled receptors and tyrosine kinases regulating cell growth, calcium metabolism, and protein kinase C activity. This gene encodes an enzyme which regulates the amount of phosphatidylinositol available for signaling by catalyzing the conversion of phosphatidic acid to CDP-diacylglycerol. This enzyme is an integral membrane protein localized to two subcellular domains, the matrix side of the inner mitochondrial membrane where it is thought to be involved in the synthesis of phosphatidylglycerol and cardiolipin.^[8]^[9] and the cytoplasmic side of the endoplasmic reticulum where it functions in phosphatidylinositol biosynthesis. Two genes encoding this enzyme have been identified in humans, one mapping to human chromosome 4q21 (this gene) and a second (CDS2) to 20p13.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000163624 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029330 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Halford S, Dulai KS, Daw SC, Fitzgibbon J, Hunt DM (November 1998). "Isolation and chromosomal localization of two human CDP-diacylglycerol synthase (CDS) genes". Genomics. 54 (1): 140–4. doi:10.1006/geno.1998.5547. PMID 9806839.
^ Weeks R, Dowhan W, Shen H, Balantac N, Meengs B, Nudelman E, Leung DW (March 1997). "Isolation and expression of an isoform of human CDP-diacylglycerol synthase cDNA". DNA and Cell Biology. 16 (3): 281–9. doi:10.1089/dna.1997.16.281. PMID 9115637.
^ ^a ^b "Entrez Gene: CDS1 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1".
^ Nowicki M, Müller F, Frentzen M (April 2005). "Cardiolipin synthase of Arabidopsis thaliana". FEBS Letters. 579 (10): 2161–5. doi:10.1016/j.febslet.2005.03.007. PMID 15811335. S2CID 21937549.
^ Nowicki M (2006). Characterization of the Cardiolipin Synthase from Arabidopsis thaliana (Ph.D. Thesis thesis). RWTH-Aachen University. Archived from the original on 2011-10-05. Retrieved 2011-07-11.

External links

Human CDS1 genome location and CDS1 gene details page in the UCSC Genome Browser.

Transferases: phosphorus-containing groups (EC 2.7)

2.7.1-2.7.4:
phosphotransferase/kinase
(PO₄)

2.7.1: OH acceptor	Hexo- Gluco- Fructo- Hepatic Galacto- Phosphofructo- 1 Liver Muscle Platelet 2 Riboflavin Shikimate Thymidine ADP-thymidine NAD⁺ Glycerol Pantothenate Mevalonate Pyruvate Deoxycytidine PFP Diacylglycerol Phosphoinositide 3 Class I PI 3 Class II PI 3 Sphingosine Glucose-1,6-bisphosphate synthase
2.7.2: COOH acceptor	Phosphoglycerate Aspartate kinase
2.7.3: N acceptor	Creatine
2.7.4: PO₄ acceptor	Phosphomevalonate Adenylate Nucleoside-diphosphate Uridylate Guanylate Thiamine-diphosphate

2.7.6: diphosphotransferase
(P₂O₇)

2.7.7: nucleotidyltransferase
(PO₄-nucleoside)

Polymerase

DNA polymerase	DNA-directed DNA polymerase I/A γ θ ν T7 Taq II/B α δ ε ζ Pfu III/C IV/X β λ μ TDT V/Y η ι κ RNA-directed DNA polymerase Reverse transcriptase Telomerase
RNA polymerase	Template-directed RNA polymerase I II III IV V ssRNAP POLRMT Primase 1 2 PrimPol RNA-dependent RNA polymerase Polyadenylation PAP PNPase

Phosphorolytic
3' to 5' exoribonuclease

Nucleotidyltransferase

Guanylyltransferase

mRNA capping enzyme

Other

2.7.8: miscellaneous

Phosphatidyltransferases	CDP-diacylglycerol—glycerol-3-phosphate 3-phosphatidyltransferase CDP-diacylglycerol—serine O-phosphatidyltransferase CDP-diacylglycerol—inositol 3-phosphatidyltransferase CDP-diacylglycerol—choline O-phosphatidyltransferase
Glycosyl-1-phosphotransferase	N-acetylglucosamine-1-phosphate transferase

2.7.10-2.7.13: protein kinase
(PO₄; protein acceptor)

2.7.10: protein-tyrosine	see tyrosine kinases
2.7.11: protein-serine/threonine	see serine/threonine-specific protein kinases
2.7.12: protein-dual-specificity	see serine/threonine-specific protein kinases
2.7.13: protein-histidine	Protein-histidine pros-kinase Protein-histidine tele-kinase Histidine kinase

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)