BICD1

Protein-coding gene in humans
BICD1
Available structures
PDBOrtholog search: PDBe RCSB
List of PDB id codes

4YTD

Identifiers
AliasesBICD1, BICD, BICD cargo adaptor 1, bic-D 1
External IDsOMIM: 602204; MGI: 1101760; HomoloGene: 37518; GeneCards: BICD1; OMA:BICD1 - orthologs
Gene location (Human)
Chromosome 12 (human)
Chr.Chromosome 12 (human)[1]
Chromosome 12 (human)
Genomic location for BICD1
Genomic location for BICD1
Band12p11.21Start32,106,835 bp[1]
End32,383,633 bp[1]
Gene location (Mouse)
Chromosome 6 (mouse)
Chr.Chromosome 6 (mouse)[2]
Chromosome 6 (mouse)
Genomic location for BICD1
Genomic location for BICD1
Band6|6 G3Start149,310,384 bp[2]
End149,464,827 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • ventricular zone

  • sural nerve

  • ganglionic eminence

  • cerebellar vermis

  • right uterine tube

  • caput epididymis

  • trigeminal ganglion

  • spinal ganglia

  • left ovary

  • paraflocculus of cerebellum
Top expressed in
  • sciatic nerve

  • mammillary body

  • ventromedial nucleus

  • lateral septal nucleus

  • lateral hypothalamus

  • substantia nigra

  • lobe of cerebellum

  • lateral geniculate nucleus

  • ventral tegmental area

  • habenula
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • dynactin binding
  • structural constituent of cytoskeleton
  • proteinase activated receptor binding
  • protein binding
  • cytoskeletal anchor activity
  • dynein complex binding
  • protein kinase binding
  • dynein intermediate chain binding
Cellular component
  • Golgi apparatus
  • membrane
  • host cell viral assembly compartment
  • trans-Golgi network
  • tubulin complex
  • perinuclear region of cytoplasm
  • cytoplasmic microtubule
  • cytoskeleton
  • cytoplasmic vesicle
  • cytosol
  • centrosome
Biological process
  • protein localization to organelle
  • regulation of proteinase activated receptor activity
  • positive regulation of receptor-mediated endocytosis
  • RNA processing
  • microtubule anchoring at microtubule organizing center
  • negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
  • negative regulation of phospholipase C activity
  • anatomical structure morphogenesis
  • intracellular mRNA localization
  • minus-end-directed organelle transport along microtubule
  • viral process
  • stress granule assembly
  • transport
  • regulation of microtubule cytoskeleton organization
  • positive regulation of protein localization to centrosome
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

636

12121

Ensembl

ENSG00000151746

ENSMUSG00000003452

UniProt

Q96G01

Q8BR07

RefSeq (mRNA)
NM_001003398
NM_001714
NM_001354186
NM_001354187
NM_001354188

NM_001354189
NM_001363603

NM_001112796
NM_009753

RefSeq (protein)
NP_001003398
NP_001705
NP_001341115
NP_001341116
NP_001341117

NP_001341118
NP_001350532

NP_001106267
NP_033883

Location (UCSC)Chr 12: 32.11 – 32.38 MbChr 6: 149.31 – 149.46 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Bicaudal D cargo adaptor 1 is a protein that in humans is encoded by the BICD1 gene.[5][6]

Function

This gene is one of two human homologs of Drosophila bicaudal-D. It has been implicated in COPI-independent membrane transport from the Golgi apparatus to the endoplasmic reticulum. Two alternative splice variants have been described. Other alternative splice variants that encode different protein isoforms have been described but their full-length nature has not been determined.[6]

Interactions

BICD1 has been shown to interact with RAB6A.[7][8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000151746 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000003452 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Baens M, Marynen P (Nov 1997). "A human homologue (BICD1) of the Drosophila bicaudal-D gene". Genomics. 45 (3): 601–6. doi:10.1006/geno.1997.4971. PMID 9367685.
  6. ^ a b "Entrez Gene: BICD1 bicaudal D homolog 1 (Drosophila)".
  7. ^ Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (Oct 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Current Biology. 12 (20): 1792–5. Bibcode:2002CBio...12.1792S. doi:10.1016/S0960-9822(02)01221-6. PMID 12401177. S2CID 14031165.
  8. ^ Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (December 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nature Cell Biology. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383. S2CID 7953140.

External links

Further reading

  • Barr FA, Short B (August 2003). "Golgins in the structure and dynamics of the Golgi apparatus". Current Opinion in Cell Biology. 15 (4): 405–13. doi:10.1016/S0955-0674(03)00054-1. PMID 12892780.
  • Claussen M, Suter B (November 2005). "BicD-dependent localization processes: from Drosophilia development to human cell biology". Annals of Anatomy - Anatomischer Anzeiger. 187 (5–6): 539–53. doi:10.1016/j.aanat.2005.07.004. PMID 16320833.
  • Baens M, Aerssens J, van Zand K, Van den Berghe H, Marynen P (September 1995). "Isolation and regional assignment of human chromosome 12p cDNAs". Genomics. 29 (1): 44–52. doi:10.1006/geno.1995.1213. PMID 8530100.
  • Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA (October 2002). "The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes". Current Biology. 12 (20): 1792–5. Bibcode:2002CBio...12.1792S. doi:10.1016/S0960-9822(02)01221-6. PMID 12401177. S2CID 14031165.
  • Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC (December 2002). "Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex". Nature Cell Biology. 4 (12): 986–92. doi:10.1038/ncb891. PMID 12447383. S2CID 7953140.
  • Tomsig JL, Snyder SL, Creutz CE (Mar 2003). "Identification of targets for calcium signaling through the copine family of proteins. Characterization of a coiled-coil copine-binding motif". The Journal of Biological Chemistry. 278 (12): 10048–54. doi:10.1074/jbc.M212632200. PMID 12522145.
  • Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (Jan 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Fuchs E, Short B, Barr FA (2006). "Assay and Properties of Rab6 Interaction with Dynein–Dynactin Complexes". GTPases Regulating Membrane Targeting and Fusion. Methods in Enzymology. Vol. 403. pp. 607–18. doi:10.1016/S0076-6879(05)03053-3. ISBN 978-0-12-182808-0. PMID 16473624.
  • Moorhead AR, Rzomp KA, Scidmore MA (Feb 2007). "The Rab6 effector Bicaudal D1 associates with Chlamydia trachomatis inclusions in a biovar-specific manner". Infection and Immunity. 75 (2): 781–91. doi:10.1128/IAI.01447-06. PMC 1828475. PMID 17101644.
  • Fumoto K, Hoogenraad CC, Kikuchi A (December 2006). "GSK-3beta-regulated interaction of BICD with dynein is involved in microtubule anchorage at centrosome". The EMBO Journal. 25 (24): 5670–82. doi:10.1038/sj.emboj.7601459. PMC 1698904. PMID 17139249.
  • Wanschers BF, van de Vorstenbosch R, Schlager MA, Splinter D, Akhmanova A, Hoogenraad CC, Wieringa B, Fransen JA (Oct 2007). "A role for the Rab6B Bicaudal-D1 interaction in retrograde transport in neuronal cells". Experimental Cell Research. 313 (16): 3408–20. doi:10.1016/j.yexcr.2007.05.032. PMID 17707369.


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