Aldehyde dehydrogenase 9 family, member A1

Protein-coding gene in the species Homo sapiens

ALDH9A1

Identifiers

Aliases

ALDH9A1, ALDH4, ALDH7, ALDH9, E3, TMABADH, aldehyde dehydrogenase 9 family member A1, TMABA-DH, TMABALDH

External IDs

OMIM: 602733; MGI: 1861622; HomoloGene: 55483; GeneCards: ALDH9A1; OMA:ALDH9A1 - orthologs

EC number

1.2.1.3

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1q24.1	Start	165,662,216 bp^[1]
Band	1q24.1	End	165,698,562 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 1 (mouse)^[2]

Band	1\|1 H2.3	Start	167,177,560 bp^[2]
Band	1\|1 H2.3	End	167,196,101 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

right adrenal cortex

left adrenal gland

left adrenal cortex

salivary gland

minor salivary glands

mucosa of esophagus

left lobe of thyroid gland

right lobe of thyroid gland

liver

corpus callosum

Top expressed in

left lobe of liver

retinal pigment epithelium

Paneth cell

crypt of lieberkuhn of small intestine

human kidney

migratory enteric neural crest cell

ciliary body

jejunum

ileum

decidua

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	aldehyde dehydrogenase (NAD+) activity oxidoreductase activity aminobutyraldehyde dehydrogenase activity 1-pyrroline dehydrogenase activity 4-trimethylammoniobutyraldehyde dehydrogenase activity 3-chloroallyl aldehyde dehydrogenase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
Cellular component	cytoplasm extracellular exosome cytosol
Biological process	cellular aldehyde metabolic process hormone metabolic process metabolism neurotransmitter biosynthetic process carnitine biosynthetic process
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


223


56752

Ensembl


ENSG00000143149


ENSMUSG00000026687

UniProt


P49189


Q9JLJ2

RefSeq (mRNA)


NM_000696 NM_001365774


NM_019993

RefSeq (protein)


NP_000687 NP_001352703

NP_064377 NP_001389759 NP_001389768 NP_001389769 NP_001389773
NP_001389774 NP_001389775 NP_001392024

Location (UCSC)

Chr 1: 165.66 – 165.7 Mb

Chr 1: 167.18 – 167.2 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

4-trimethylaminobutyraldehyde dehydrogenase is an enzyme that in humans is encoded by the ALDH9A1 gene.^[5]^[6]^[7]

Function

This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000143149 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000026687 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ McPherson JD, Wasmuth JJ, Kurys G, Pietruszko R (February 1994). "Human aldehyde dehydrogenase: chromosomal assignment of the gene for the isozyme that metabolizes gamma-aminobutyraldehyde". Human Genetics. 93 (2): 211–2. doi:10.1007/bf00210615. PMID 8112751. S2CID 26773065.
^ Lin SW, Chen JC, Hsu LC, Hsieh CL, Yoshida A (June 1996). "Human gamma-aminobutyraldehyde dehydrogenase (ALDH9): cDNA sequence, genomic organization, polymorphism, chromosomal localization, and tissue expression". Genomics. 34 (3): 376–80. doi:10.1006/geno.1996.0300. PMID 8786138.
^ ^a ^b "Entrez Gene: ALDH9A1 aldehyde dehydrogenase 9 family, member A1".

External links

Human ALDH9A1 genome location and ALDH9A1 gene details page in the UCSC Genome Browser.

Kurys G, Ambroziak W, Pietruszko R (March 1989). "Human aldehyde dehydrogenase. Purification and characterization of a third isozyme with low Km for gamma-aminobutyraldehyde". The Journal of Biological Chemistry. 264 (8): 4715–21. doi:10.1016/S0021-9258(18)83802-9. PMID 2925663.
Kurys G, Shah PC, Kikonygo A, Reed D, Ambroziak W, Pietruszko R (December 1993). "Human aldehyde dehydrogenase. cDNA cloning and primary structure of the enzyme that catalyzes dehydrogenation of 4-aminobutyraldehyde". European Journal of Biochemistry. 218 (2): 311–20. doi:10.1111/j.1432-1033.1993.tb18379.x. PMID 8269919.
Kikonyogo A, Pietruszko R (May 1996). "Aldehyde dehydrogenase from adult human brain that dehydrogenates gamma-aminobutyraldehyde: purification, characterization, cloning and distribution". The Biochemical Journal. 316 ( Pt 1) (1): 317–24. doi:10.1042/bj3160317. PMC 1217341. PMID 8645224.
Izaguirre G, Kikonyogo A, Pietruszko R (September 1997). "Tissue distribution of human aldehyde dehydrogenase E3 (ALDH9): comparison of enzyme activity with E3 protein and mRNA distribution". Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 118 (1): 59–64. doi:10.1016/s0305-0491(97)00022-9. PMID 9417993.
Vaz FM, Fouchier SW, Ofman R, Sommer M, Wanders RJ (March 2000). "Molecular and biochemical characterization of rat gamma-trimethylaminobutyraldehyde dehydrogenase and evidence for the involvement of human aldehyde dehydrogenase 9 in carnitine biosynthesis". The Journal of Biological Chemistry. 275 (10): 7390–4. doi:10.1074/jbc.275.10.7390. PMID 10702312.
Izaguirre G, Pietruszko R, Cho S, MacKerell A (December 2001). "Human aldehyde dehydrogenase catalytic activity and structural interactions with coenzyme analogs". Journal of Biomolecular Structure & Dynamics. 19 (3): 429–47. doi:10.1080/07391102.2001.10506752. PMID 11790142. S2CID 35621262.