AFAP1

Protein-coding gene in the species Homo sapiens
AFAP1
Identifiers
AliasesAFAP1, AFAP, AFAP-110, AFAP110, actin filament associated protein 1
External IDsOMIM: 608252; MGI: 1917542; HomoloGene: 11009; GeneCards: AFAP1; OMA:AFAP1 - orthologs
Gene location (Human)
Chromosome 4 (human)
Chr.Chromosome 4 (human)[1]
Chromosome 4 (human)
Genomic location for AFAP1
Genomic location for AFAP1
Band4p16.1Start7,758,714 bp[1]
End7,939,926 bp[1]
Gene location (Mouse)
Chromosome 5 (mouse)
Chr.Chromosome 5 (mouse)[2]
Chromosome 5 (mouse)
Genomic location for AFAP1
Genomic location for AFAP1
Band5|5 B3Start36,050,663 bp[2]
End36,161,267 bp[2]
RNA expression pattern
Bgee
HumanMouse (ortholog)
Top expressed in
  • stromal cell of endometrium

  • sural nerve

  • right testis

  • left testis

  • ganglionic eminence

  • muscle layer of sigmoid colon

  • epithelium of colon

  • popliteal artery

  • tibial arteries

  • testicle
Top expressed in
  • pineal gland

  • decidua

  • iris

  • belly cord

  • aorta

  • superior cervical ganglion

  • otolith organ

  • calvaria

  • utricle

  • atrium
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
  • actin binding
  • SH3 domain binding
  • SH2 domain binding
Cellular component
  • cytoplasm
  • cytoskeleton
  • focal adhesion
  • cytosol
  • actin cytoskeleton
Biological process
  • regulation of signal transduction
  • regulation of cytoskeleton organization
Sources:Amigo / QuickGO
Orthologs
SpeciesHumanMouse
Entrez

60312

70292

Ensembl

ENSG00000196526

ENSMUSG00000029094

UniProt

Q8N556

Q80YS6

RefSeq (mRNA)

NM_001134647
NM_021638
NM_198595
NM_001371090
NM_001371091

NM_027373

RefSeq (protein)

NP_001128119
NP_940997
NP_001358019
NP_001358020

NP_081649
NP_001390348
NP_001390349
NP_001390350

Location (UCSC)Chr 4: 7.76 – 7.94 MbChr 5: 36.05 – 36.16 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Actin filament-associated protein 1 is a protein that in humans is encoded by the AFAP1 gene.[5][6][7][8]

The protein encoded by this gene is a Src binding partner. It may represent a potential modulator of actin filament integrity in response to cellular signals, and may function as an adaptor protein by linking Src family members and/or other signaling proteins to actin filaments. Two alternative transcripts encoding the same protein have been identified.[8]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000196526 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029094 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Qian Y, Gatesman AS, Baisden JM, Zot HG, Cherezova L, Qazi I, Mazloum N, Lee MY, Guappone-Koay A, Flynn DC (Feb 2004). "Analysis of the role of the leucine zipper motif in regulating the ability of AFAP-110 to alter actin filament integrity". J Cell Biochem. 91 (3): 602–20. doi:10.1002/jcb.10725. PMID 14755689. S2CID 38130241.
  6. ^ Baisden JM, Gatesman AS, Cherezova L, Jiang BH, Flynn DC (Oct 2001). "The intrinsic ability of AFAP-110 to alter actin filament integrity is linked with its ability to also activate cellular tyrosine kinases". Oncogene. 20 (45): 6607–16. doi:10.1038/sj.onc.1204802. PMID 11641786. S2CID 21926408.
  7. ^ Baisden JM, Qian Y, Zot HM, Flynn DC (Oct 2001). "The actin filament-associated protein AFAP-110 is an adaptor protein that modulates changes in actin filament integrity". Oncogene. 20 (44): 6435–47. doi:10.1038/sj.onc.1204784. PMID 11607843.
  8. ^ a b "Entrez Gene: AFAP1 actin filament associated protein 1".

External links

Further reading

  • Ishida Y, Hadano S, Nagayama T, et al. (1995). "Isolation and characterization of 21 novel expressed DNA sequences from the distal region of human chromosome 4p". Genomics. 22 (2): 302–12. doi:10.1006/geno.1994.1388. PMID 7545969.
  • Qian Y, Baisden JM, Westin EH, et al. (1998). "Src can regulate carboxy terminal interactions with AFAP-110, which influence self-association, cell localization and actin filament integrity". Oncogene. 16 (17): 2185–95. doi:10.1038/sj.onc.1201753. PMID 9619827. S2CID 28373925.
  • Guappone AC, Weimer T, Flynn DC (1998). "Formation of a stable src-AFAP-110 complex through either an amino-terminal or a carboxy-terminal SH2-binding motif". Mol. Carcinog. 22 (2): 110–9. doi:10.1002/(SICI)1098-2744(199806)22:2<110::AID-MC6>3.0.CO;2-Q. PMID 9655255. S2CID 10461528.
  • Qian Y, Baisden JM, Zot HG, et al. (2000). "The carboxy terminus of AFAP-110 modulates direct interactions with actin filaments and regulates its ability to alter actin filament integrity and induce lamellipodia formation". Exp. Cell Res. 255 (1): 102–13. doi:10.1006/excr.1999.4795. PMID 10666339.
  • Qian Y, Baisden JM, Cherezova L, et al. (2003). "PC phosphorylation increases the ability of AFAP-110 to cross-link actin filaments". Mol. Biol. Cell. 13 (7): 2311–22. doi:10.1091/mbc.E01-12-0148. PMC 117315. PMID 12134071.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
  • Brandenberger R, Wei H, Zhang S, et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197. S2CID 27764390.
  • Ballif BA, Villén J, Beausoleil SA, et al. (2005). "Phosphoproteomic analysis of the developing mouse brain". Mol. Cell. Proteomics. 3 (11): 1093–101. doi:10.1074/mcp.M400085-MCP200. PMID 15345747.
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
  • Dorfleutner A, Stehlik C, Zhang J, et al. (2007). "AFAP-110 is required for actin stress fiber formation and cell adhesion in MDA-MB-231 breast cancer cells". J. Cell. Physiol. 213 (3): 740–9. CiteSeerX 10.1.1.636.3591. doi:10.1002/jcp.21143. PMID 17520695. S2CID 15344259.


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